All-trans-Retinoic Acid Prevents Radiation- or Bleomycin-induced Pulmonary Fibrosis
نویسندگان
چکیده
منابع مشابه
All-trans-retinoic acid prevents radiation- or bleomycin-induced pulmonary fibrosis.
RATIONALE Although radiotherapy is effective in treating lung cancers, resultant pulmonary injury is the main obstacle. Pulmonary fibrosis is characterized by progressive worsening in pulmonary function leading to high incidence of death. Currently, however, there has been little progress in effective preventive and therapeutic strategies. OBJECTIVES Previously, we reported that all-trans-ret...
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A 5-year-old girl presented with fever, skin and mucosal bleeds, and pallor. Her hemoglobin was 3.6 g/dL, total white cell count 4.5×103/μL and platelet count 13×103/μL. Peripheral smear revealed 30% blasts, confirmed as APML on bone marrow examination. Cytogenetic analysis showed the typical translocation of t(15:17) with 77% of interphase cells expressing PML:RARA gene fusion. Child was start...
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Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in rats. The aim of this study was to evaluate the effects of saffron aqueous extract on this disorder paving the way for more investigation in treating idiopathic pulmonary fibrosis in human. Methods: Male Wistar rats (250–300 gr) were instilled a single dose of bleomycin (5 mg/kg) via in...
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Pulmonary fibrosis in humans can occur as a result of a large number of conditions. In idiopathic pulmonary fibrosis (IPF), pulmonary function becomes progressively compromised resulting in a high mortality rate. Currently there are no proven effective treatments for IPF. We have recently reported that IL-6 and TGF-beta(1) plays an important role in proliferation and differentiation of lung fib...
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Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibro-proliferative disorder of unknown etiology, with no effective treatment regimen, and a median survival of just 3–5 years following diagnosis [1]. Pulmonary Hypertension (PH) often complicates IPF and is associated with higher mortality. Augmentation of endogenous natriuretic peptide (NP) stimulated cGMP, using a neutral endop...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2006
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.200606-862oc